Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology The multiple mechanisms and modes of cell death after acetaminophen overdose ACETAMINOPHEN INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE The Journal of Pharmacology and Experimental Therapeutics