Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports