Acetaminophen (4 Acetamidophenol, APAP, 4' Hydroxyacetanilide, NSC 3991, NSC 109028, Paracetamol, CAS Number: 103 90 2) Cayman Chemical PARACETAMOL DEPLETES GLUTATHIONE Natural Healing Centre Sex differences in glutathione metabolism and acetaminophen toxicity Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function,